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KMID : 0869220190230010028
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Journal of Korean Geriatric Psychiatry
2019 Volume.23 No. 1 p.28 ~ p.32
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Development of a Screening Algorithm for Alzheimer’s Disease Using Categorical Fluency and Confrontational Naming Abilities
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Chi Yeon-Kyung
Han Ji-Won Esther
Park Sun-Young
Kim Tae-Hui
Lee Jung-Jae
Lee Seok-Bum
Park Joon-Hyuk
Youn Jong-Chul
Kim Jeong-Lan
Ryu Seung-Ho
Jhoo Jin-Hyeong
Kim Ki-Woong
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Abstract
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Objective：Declines in naming ability and semantic memory are well-known features of early Alzheimer’s disease (AD). We developed a new screening algorithm for AD using two brief language tests : the Categorical Fluency Test (CFT) and 15-item Boston Naming Test (BNT15).
Methods：We administered the CFT, BNT15, and Mini-Mental State Examination (MMSE) to 150 AD patients with a Clinical Dementia Rating of 0.5 or 1 and to their age- and gender-matched cognitively normal controls. We developed a composite score for screening AD (LANGuage Composite score, LANG-C) that comprised demographic characteristics, BNT15 subindices, and CFT subindices. We compared the diagnostic accuracies of the LANG-C and MMSE using receiver operating curve analysis.
Results：The LANG-C was calculated using the logit of test scores weighted by their coefficients from forward stepwise logistic regression models : logit (case)=12.608-0.107×age+1.111×gender+0.089×education-0.314×HS1st-0.362×HS2nd+0.455×perseveration+ 1.329×HFCR2nd-0.489×MFCR1st-0.565×LFCR3rd. The area under the curve of the LANG-C for diagnosing AD was good (0.894, 95% confidence interval=0.853-0.926 ; sensitivity=0.787, specificity=0.840), although it was smaller than that of the MMSE.
Conclusion：The LANG-C, which is easy to automate using PC or smart devices and to deliver widely via internet, can be a good alternative for screening AD to MMSE.
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KEYWORD
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Alzheimer’s disease, Boston Naming Test, Categorical Fluency Test, Mini-Mental State Examination, Naming ability, Screening, Semantic memory
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